P. Milanov, N. Pencheva: The mathematics of drug- receptor interaction

Abstract: The following items are discussed:
1. Experimental evidence;
2. Application of the law of mass action to drug-receptor interaction;
3. The relationship between receptor-occupation and the observed response;
4. Clark's quantitative treatment of receptor theory;
5. Application of the null method to studies of drug antagonism;
6. Intrinsic activity;
7. Efficacy;
8. The stimulus-response relationship;
9. Comparison of intrinsic activity and efficacy;
10. Furchgott's method for the determination of the
affinity constants of agonists for receptors;
11. Waud and Barlow's method for partial agonists;
12. A general method for the analysis of drug-receptor interaction: a) application to reversible interactions;
b) application to irreversible antagonism;
13. Operational models for the analysis of drug- receptor interaction;
14. Hyperbolic model of partial agonism;
15. Experimental considerations.